Infections in non-HIV immunosuppressed patients and healthcare-associated infections
The objective of the program is the investigation of epidemiological, pathogenic, clinical, preventive and therapeutic aspects of infectious complications in immunocompromised hosts (excluding HIV infection). The program will promote the extension of this research to horizons beyond the classic concept of the immunocompromised host, favoring the study of the bases of the immune response that regulates infection and incorporating new biological therapies for the treatment of infectious diseases. The program will also investigate infections related to health care not included in other CIBERINFEC programs, and will try to incorporate the knowledge acquired in immunocompromised patients into the treatment of these infections.
Specific objectives: lines of research
- Epidemiological studies to analyze the incidence and risk factors of opportunistic or community infection in immunocompromised patients.
- Evaluation of immunological and genetic variables that influence the infection of the immunocompromised patient and in patients with other healthcare-associated infections.
- Analysis of the role of the innate and adaptive immune response in the infection of the immunocompromised patient and in some community-associated infections.
- Study of the deleterious effect of iatrogenic immunosuppression, including new biological therapies, CAR-T, and checkpoint inhibitors, on the risk of infection.
- Analysis of markers that allow us to assess the degree of immunosuppression in the immunocompromised patient.
- Trials aimed at reducing the impact of viral infection (especially, but not only, CMV) through immuno-guided prophylaxis.
- Evaluate the role of community respiratory viruses and analyze the immune basis of the infection and the vaccine response to it.
- Efficacy and safety of therapeutic and preventive strategies, especially through intervention studies, of the most serious and/or most frequent healthcare-associated infections.
- Clinical research studies of specific infections in elderly people residing in health centers.
- Study of healthcare-associated infections through a multidisciplinary approach, from basic research to clinical management of patients, with special attention to the importance of biomedical implants in the etiopathogenesis, prevention and management of these infections.